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>Descriptive Analysis Of And Overall Survival After Surgical Treatment Of Lung Metastases [análise Descritiva E Sobrevida Global Do Tratamento Cirúrgico Das Metástases Pulmonares]
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Descriptive Analysis Of And Overall Survival After Surgical Treatment Of Lung Metastases [análise Descritiva E Sobrevida Global Do Tratamento Cirúrgico Das Metástases Pulmonares]
Objective: To describe demographic characteristics, surgical results, postoperative complications, and overall survival rates in surgically treated patients with lung metastases. Methods: This was a retrospective analysis of 119 patients who underwent a total of 154 lung metastasis resections between 1997 and 2011. Results: Among the 119 patients, 68 (57.1%) were male and 108 (90.8%) were White. The median age was 52 years (range, 15-75 years). In this sample, 63 patients (52.9%) presented with comorbidities, the most common being systemic arterial hypertension (69.8%) and diabetes (19.0%). Primary colorectal tumors (47.9%) and musculoskeletal tumors (21.8%) were the main sites of origin of the metastases. Approximately 24% of the patients underwent more than one resection of the lesions, and 71% had adjuvant treatment prior to metastasectomy. The rate of lung metastasis recurrence was 19.3%, and the median disease-free interval was 23 months. The main surgical access used was thoracotomy (78%), and the most common approach was wedge resection with segmentectomy (51%). The rate of postoperative complications was 22%, and perioperative mortality was 1.9%. The overall survival rates at 12, 36, 60, and 120 months were 96%, 77%, 56%, and 39%, respectively. A Cox analysis confirmed that complications within the first 30 postoperative days were associated with poor prognosis (hazard ratio = 1.81; 95% CI: 1.09-3.06; p = 0.02). Conclusions: Surgical treatment of lung metastases is safe and effective, with good overall survival, especially in patients with fewer metastases.
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机译:目的:描述经手术治疗的肺转移患者的人口统计学特征,手术结果,术后并发症和总生存率。方法:这是对1997年至2011年间共进行154例肺转移切除术的119例患者的回顾性分析。结果:119例患者中,男性68例(57.1%),白人108例(90.8%)。中位年龄为52岁(范围为15-75岁)。在该样本中,有63名患者(52.9%)出现合并症,最常见的是全身性动脉高压(69.8%)和糖尿病(19.0%)。原发性结直肠肿瘤(47.9%)和肌肉骨骼肿瘤(21.8%)是转移灶的主要起源部位。大约24%的患者接受了一次以上的病灶切除,而71%的患者在转移灶切除之前接受了辅助治疗。肺转移复发率为19.3%,中位无病间隔时间为23个月。使用的主要手术途径是开胸手术(78%),最常见的方法是采用节段切除术进行楔形切除(51%)。术后并发症发生率为22%,围手术期死亡率为1.9%。在12、36、60和120个月时的总生存率分别为96%,77%,56%和39%。 Cox分析证实,术后30天内的并发症与预后不良相关(危险比= 1.81; 95%CI:1.09-3.06; p = 0.02)。结论:手术治疗肺转移瘤是安全有效的,总体生存率较高,尤其是对于转移较少的患者。
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